643 Grand AV South San Francisco CA 94080 | MLS #ML82059314
Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.
Property Details
Price:
$998,888
MLS #:
ML82059314
Status:
Active
Beds:
3
Baths:
4
Type:
Single Family
Subtype:
Single Family Residence
Neighborhood:
699notdefined
Listed Date:
Aug 27, 2026
Finished Sq Ft:
1,630
Lot Size:
3,500 sqft / 0.08 acres (approx)
Year Built:
1895
See this Listing
Schools
School District:
South San Francisco Unified
Interior
Appliances
DW, GD, RF
Bathrooms
4 Full Bathrooms
Cooling
NO
Flooring
WOOD
Heating
CF
Exterior
Common Walls
NCW
Garage Spaces
2
Parking Spots
2
Parking Total
2
Roof
SHN
Window Features
SK
Financial
Map
Community
- Address643 Grand AV South San Francisco CA
- CitySouth San Francisco
- CountySan Mateo
- Zip Code94080
Subdivisions in South San Francisco
Market Summary
Current real estate data for Single Family in South San Francisco as of Oct 01, 2026
45
Single Family Listed
33
Avg DOM
868
Avg $ / SqFt
$1,257,769
Avg List Price
Property Summary
- 643 Grand AV South San Francisco CA is a Single Family for sale in South San Francisco, CA, 94080. It is listed for $998,888 and features 3 beds, 4 baths, and has approximately 1,630 square feet of living space, and was originally constructed in 1895. The current price per square foot is $613. The average price per square foot for Single Family listings in South San Francisco is $868. The average listing price for Single Family in South San Francisco is $1,257,769. To schedule a showing of MLS#ml82059314 at 643 Grand AV in South San Francisco, CA, contact your Compass agent at 310.409.7242.
Similar Listings Nearby
Courtesy of Christie’s International Real Estate Sereno. Disclaimer: All data relating to real estate for sale on this page comes from the Broker Reciprocity (BR) of the California Regional Multiple Listing Service. Detailed information about real estate listings held by brokerage firms other than Compass include the name of the listing broker. Neither the listing company nor Compass shall be responsible for any typographical errors, misinformation, misprints and shall be held totally harmless. The Broker providing this data believes it to be correct, but advises interested parties to confirm any item before relying on it in a purchase decision. Copyright 2026. California Regional Multiple Listing Service. All rights reserved.643 Grand AV
South San Francisco, CA
